HU LY-M3—A HUMAN LEUKOCYTE ANTIGEN

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Abstract
A monoclonal antibody, 5-4.8, was produced against human peripheral blood lymphocytes and it appeared to be leukocyte-specific in that it reacted with a common determinant (called Hu Ly-m3) present on the peripheral blood T, B and null lymphocytes of 40 individuals. The antibody also reacts with thymocytes, spleen cells and bone marrow cells (30%) and weakly with granulocytes and platelets.sbd.but not with heart, liver or kidney. Affinity to lentil-lectin and MW analysis demonstrated that Hu Ly-m3 is a glycoprotein consisting of a single chain of 47,000 daltons which is not HLA because it is not present on all cells, because it is present on the surface of the phenotypically HLA- Daudi cell line, and because soluble HLA antigens did not inhibit the binding of the 5-4.8 antibody.

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