A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly
Top Cited Papers
- 24 March 2006
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 24,p. 2566-2568
- https://doi.org/10.1039/b600382f
Abstract
A flow process for the multi-step synthesis of the alkaloid natural product (±)-oxomaritidine is described, mediated through the use of microfluidic pumping systems that progress material through various packed columns containing immobilized reagents, catalysts, scavengers or catch and release agents; our route involves the combination of seven separate synthetic steps linked into one continuous sequence utilizing flow chemistry.Keywords
This publication has 23 references indexed in Scilit:
- The rapid preparation of 2-aminosulfonamide-1,3,4-oxadiazoles using polymer-supported reagents and microwave heatingTetrahedron, 2005
- Automated Flow-Through Synthesis of Heterocyclic ThioethersJournal of Combinatorial Chemistry, 2004
- Continuous Flow Techniques in Organic SynthesisChemistry – A European Journal, 2003
- Microfluidic combinatorial chemistryCurrent Opinion in Chemical Biology, 2003
- New tools and concepts for modern organic synthesisNature Reviews Drug Discovery, 2002
- Micro reactors: principles and applications in organic synthesisTetrahedron, 2002
- Asymmetric Catalysis on Sequentially-Linked ColumnsJournal of the American Chemical Society, 2001
- The application of micro reactors to synthetic chemistryChemical Communications, 2001
- Multi-step organic synthesis using solid-supported reagents and scavengers: a new paradigm in chemical library generationJournal of the Chemical Society, Perkin Transactions 1, 2000
- Column Asymmetric Catalysis for β-Lactam SynthesisOrganic Letters, 2000