Platelet Aggregation Inhibiting and Anticoagulant Effects of Oligoamines, XXII: Bisoxazol‐, Bisimidazol‐, Bisthiazol‐ and Oligo‐1,2,4‐thiadiazolimines

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Abstract
One mesoionic 4,4′-propylene-bis-oxazol-5-imine (5), two 2,2′-m-phenylene-bis-imidazol-4-imines (9a,b), five 4,4′-benzene-bis-(and tris)-thiazol-2-amines (13a,b, 14a-c) and 14 3,3′-benzene-bis-(and tris)-1,2,4-thiadiazolimines (18a-o) were synthesized and assayed for their antiplatelet and anticoagulant activities. The most potent compound was the tris-thiadiazole derivative 18m which inhibited the aggregation of platelets induced by collagen at a concentration of 10 μmol/L by 50 percent (Born-test). No anticoagulant effects (Quick-test) were observed up to 400 μmol/L. In the thiazolamine series combined antiplatelet and anticoagulant activities were seen.