Platelet Aggregation Inhibiting and Anticoagulant Effects of Oligoamines, XW: Oligoamines with Fluorescent Properties Part A: Fluorescent Bridged Nitrogen Functions
- 1 January 1992
- journal article
- Published by Wiley in Archiv der Pharmazie
- Vol. 325 (4) , 235-239
- https://doi.org/10.1002/ardp.19923250408
Abstract
Eleven dimethanamines and one disydnonimine with fluorescent properties have been synthesized. All of them show antiplatelet activities (IC50, Born‐test) in concentrations between 14–75 μmol/L. Five of them inhibited fibrin formation induced by thromboplastin by more than 75% in a 200 μmolar concentration. Both effect do not run parallel. The most space consuming fluorophores show the smallest inhibition of the platelet aggregation. Best results were obtained with an azulene, acenaphthene or naphthalene moiety between the two basic nitrogen functions.Keywords
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