Effect of neuroleptic drugs on lithium uptake by the human erythrocyte
- 1 July 1979
- journal article
- research article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 26 (1) , 96-102
- https://doi.org/10.1002/cpt197926196
Abstract
We studied the effects of neuroleptic and antidepressant drugs on Li+ uptake in human red cells to examine the reported neurotoxicity reported for lithium‐neuroleptic combination treatment and its relationship to altered tissue Li+ levels. All the phenothiazines increased Li+ influx in red cells and steady‐state Li+ distribution ratio in vitro. This effect was not observed with other drugs studied. It is suggested that increased levels of Li+ in the tissue caused by phenothiazines may be related to neurotoxic effects observed during Li+‐phenothiazine therapy.This publication has 5 references indexed in Scilit:
- NEUROTOXICITY WITH COMBINED USE OF LITHIUM AND THIORIDAZINE1979
- Prediction of in vivo red cell/plasma Li+ ratios by in vitro methodsClinical Pharmacology & Therapeutics, 1978
- Sensitive gas-chromatographic determination of fluphenazine in human plasma.Clinical Chemistry, 1978
- Studies on the lithium transport across the red cell membranePflügers Archiv - European Journal of Physiology, 1977
- Studies on the lithium transport across the red cell membranePflügers Archiv - European Journal of Physiology, 1976