Building an antibody factory: a job for the unfolded protein response
- 20 December 2004
- journal article
- review article
- Published by Springer Nature in Nature Immunology
- Vol. 6 (1) , 23-29
- https://doi.org/10.1038/ni1149
Abstract
Plasma cells are highly specialized, terminally differentiated secretory cells that produce tremendous quantities of a single product, the antibody molecule. In differentiating from a quiescent B cell, the plasma cell must undergo a dramatic architectural metamorphosis. This process entails augmenting the secretory organelles and the proteins that populate them, upregulating their energy and translation potential, and increasing the quality control system to do the job. This transformation is accomplished by an interplay between B lineage–specific transcriptional programs that control plasma cell differentiation and an unfolded protein response.Keywords
This publication has 59 references indexed in Scilit:
- A role for the unfolded protein response in optimizing antibody secretionMolecular Immunology, 2004
- ER Stress Regulation of ATF6 Localization by Dissociation of BiP/GRP78 Binding and Unmasking of Golgi Localization SignalsDevelopmental Cell, 2002
- IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNANature, 2002
- XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription FactorCell, 2001
- Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell SurvivalPublished by Elsevier ,2001
- Dissociation of Kar2p/BiP from an ER Sensory Molecule, Ire1p, Triggers the Unfolded Protein Response in YeastBiochemical and Biophysical Research Communications, 2000
- tRNA Ligase Is Required for Regulated mRNA Splicing in the Unfolded Protein ResponseCell, 1996
- A transmembrane protein with a cdc 2+ CDC 28 - related kinase activity is required for signaling from the ER to the nucleusPublished by Elsevier ,1993
- Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinaseCell, 1993
- Development of rough endoplasmic reticulum in mouse splenic lymphocytes stimulated by mitogensEuropean Journal of Immunology, 1973