In vitro and In vivo Evaluation of Docetaxel Loaded Biodegradable Polymersomes

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Abstract
Formulation of docetaxel (DOC), a hydrophobic anticancer drug, was successfully achieved in poly(γ‐benzyl L‐glutamate)‐block‐hyaluronan polymersomes using a simple and reproducible nanoprecipitation method. The prepared DOC loaded polymersomes (PolyDOC) was stable either in solution or in a lyophilized form, and showed controlled release behaviour over several days. PolyDOC showed high in vitro toxicity after 24 h in MCF‐7 and U87 cells compared to free DOC. Biodistribution data demonstrated that 99mTc labelled PolyDOC t1/2 and MRT significantly increased compared to a DOC solution (DS). In addition, PolyDOC uptake in Ehrlich Ascites Tumor (EAT) tumor bearing mice was larger at each time point compared to DS, making such a polymer vesicle formulation an efficient drug nanocarrier for improved DOC cancer therapy.
Funding Information
  • Science and Technology Service, Embassy of France in India