Salicylism and Severe Brain Edema

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Abstract
To the Editor: Recently, a Journal CPC discussed a fatal case of fulminant acute hepatitis and cerebral edema in a patient treated with aspirin for probable juvenile rheumatoid arthritis.1 The CPC report came a week after a similar experience of ours in which the sudden neurologic deterioration was unexpected and nearly fatal.The diagnosis of juvenile rheumatoid arthritis had been established at the age of three years in a 5 1/2-year-old boy, who was being treated with high doses of aspirin and low doses of prednisone. One week before his last hospital admission he contracted a cold, and his . . .

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