Rat brain endoplasmic reticulum calcium pools are anatomically and functionally segregated.
- 1 September 1990
- journal article
- research article
- Published by American Society for Cell Biology (ASCB) in Cell Regulation
- Vol. 1 (10) , 781-790
- https://doi.org/10.1091/mbc.1.10.781
Abstract
Autoradiographic imaging can localize 45Ca2+ selectively accumulated via the Ca2+, Mg2(+)-ATPase into endoplasmic reticulum stores in rat brain slices. 45Ca2+ accumulation is markedly stimulated by oxalate and displays a heterogeneous distribution which resembles the mRNA distribution for a sarcoendoplasmic reticulum Ca2+, Mg2(+)-ATPase. Inositol 1,4,5-triphosphate [I(1,4,5)P3] inhibits 45Ca2+ accumulation selectively into regions corresponding to those enriched in I(1,4,5)P3 receptor-binding sites and in Ca2+, -Mg2(+)-ATPase mRNA. Thus rat brain endoplasmic reticulum calcium stores are anatomically and functionally differentiated.This publication has 32 references indexed in Scilit:
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