INFLUENCE OF THYROID STATUS ON THE ELECTROCARDIOGRAM AND CERTAIN BLOOD CONSTITUENTS OF THE SHEEP

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Abstract
The thyroid status of domestic sheep was modified experimentally by means of thyroidectomy followed by thyroprotein therapy and also by the admn. of thiouracil. Under each of the exptl. conditions data were obtained on the ecg and certain constituents of the blood. In the ecg studies, the outstanding deviations from the normal following thyroidectomy were a decrease in heart rate and in T wave height. Thyroprotein admn. at the rate of 1 and 2 g./45 kg. body wt. restored the ecg pattern to normal or above. Thiouracil admn. resulted in an atypical increase in T wave height in addition to some reduction in heart rate. The "blood fat" as detd. on serum by the method of Allen did not show the expected rise following thyroidectomy. The blood fat level declined slightly, however, after treatment with thyroprotein. Thiouracil admn. resulted in a sharp and highly significant increase in the blood fat levels. No appreciable alterations in the blood sugar level after thyroidectomy or treatment with thiouracil were noted. There was a small, but statistically insignificant, rise in the blood sugar when thyroprotein was fed. No deviations that could be related to the thyroid status were observed in the blood Hb content or the serum protein, Ca, P or Mg.