Differential loss of ancestral gene families as a source of genomic divergence in animals
Open Access
- 7 February 2004
- journal article
- research article
- Published by The Royal Society in Proceedings Of The Royal Society B-Biological Sciences
- Vol. 271 (suppl_3) , S107-S109
- https://doi.org/10.1098/rsbl.2003.0124
Abstract
A phylogenetic approach was used to reconstruct the pattern of an apparent loss of 2106 ancestral gene families in four animal genomes (Caenorhabditis elegans, Drosophila melanogaster, human and fugu). Substantially higher rates of loss of ancestral gene families were found in the invertebrates than in the vertebrates. These results indicate that the differential loss of ancestral gene families can be a significant factor in the evolutionary diversification of organisms.Keywords
This publication has 22 references indexed in Scilit:
- Estimation of divergence times from multiprotein sequences for a few mammalian species and several distantly related organismsProceedings of the National Academy of Sciences, 2001
- What If There Are Only 30,000 Human Genes?Science, 2001
- The Evolutionary Fate and Consequences of Duplicate GenesScience, 2000
- No footprints of primordial introns in a eukaryotic genomeTrends in Genetics, 2000
- Gapped BLAST and PSI-BLAST: a new generation of protein database search programsNucleic Acids Research, 1997
- Evolution by the birth-and-death process in multigene families of the vertebrate immune systemProceedings of the National Academy of Sciences, 1997
- Evidence for a clade of nematodes, arthropods and other moulting animalsNature, 1997
- Rapid evolution of immunoglobulin superfamily C2 domains expressed in immune system cellsMolecular Biology and Evolution, 1997
- Molecular mimicry and the generation of host defense protein diversityCell, 1993
- Evolution of the major histocompatibility complex: independent origin of nonclassical class I genes in different groups of mammals.Molecular Biology and Evolution, 1989