Brain Polysomes: Response to Environmental Stimulation
- 18 August 1967
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 157 (3790) , 836-838
- https://doi.org/10.1126/science.157.3790.836
Abstract
Polysomes have been isolated from rat brain and characterized by their appearance in the electron microscope and by their sedimentation in sucrose density gradients. Rats were isolated for 3 days in the dark and were then returned to the light for 15 minutes. The polysomes in brain, but not in liver, decreased in rats deprived of light and increased in those stimulated with light. These findings together with an increased capacity for protein synthesis in the brain in vitro and in vivo suggest that an increase in the activity of messenger RNA in the brain may result from environmental changes.This publication has 14 references indexed in Scilit:
- Isolation and Properties of Polyribosomes from Cerebral Cortex*Biochemistry, 1967
- Turnover of Brain Messenger RNANature, 1967
- Behavior, Neural Function, and RNAProgress in Nucleic Acid Research and Molecular Biology, 1967
- CORRELATION OF THE FUNCTIONAL ACTIVITY OF THE BRAIN WITH METABOLIC PARAMETERS—III*Journal of Neurochemistry, 1966
- The number of growing polypeptide chains on reticulocyte polyribosomesJournal of Molecular Biology, 1964
- Some Aspects of Steroid Hormone ActionAnnual Review of Biochemistry, 1963
- Ribosomal Aggregates Engaged in Protein Synthesis : Ergosome Breakdown and Messenger Ribonucleic Acid TransportNature, 1963
- Breakdown of Rat-Liver Ergosomes in vivo after Actinomycin Inhibition of Messenger RNA SynthesisScience, 1963
- Fate of a Synthetic Polynucleotide Directing Cell-Free Protein Synthesis II. Association with RibosomesScience, 1962
- Measurement of the incorporation of radioactive amino acids into protein by a filter-paper disk methodArchives of Biochemistry and Biophysics, 1961