Water Deprivation and Trichloroethylene

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Abstract
Rats with implanted hypothalamic electrodes were trained to press a lever for electrical brain stimulation during a daily 30 minute test period. In rats continuously deprived of water for three days, the rate of lever-pressing declined slightly on the first day but remained at that level during the next two days. Exposure of nondehydrated rats to high concentrations of trichloroethylene during the text periods markedly depressed the rate of pressing on three consecutive days. In rats deprived of water for three days and exposed to trichloroethylene daily, the onset of depression was delayed during each test period, and greater tolerance to trichloroethylene developed than in nondehydrated rats. When these rats were later deprived of water for ten days, the rate decreased progressively from days 5 to 10, which was not characteristic of control rats.