Localized Changes in Properties of the Blood and Effects of Anticoagulant Drugs in Experimental Cerebral Infarction

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Abstract
RECENT clinical reports have stressed beneficial effects resulting from the use of anticoagulant drugs in thrombosis of the basilar and carotid arteries1 2 3 4 and in thromboembolic cerebrovascular disease.5 , 6 It was concluded that this type of treatment improves transient symptoms due to intermittent ischemia, decreases the occurrence of cerebral embolism and thrombosis but does not alter the course of cerebral infarction once established.7 How anticoagulant drugs cause benefit in cerebrovascular disease is not fully understood. Clinical and experimental evidence indicates that after a delay such treatment may result in recanalization of a thrombosed vessel. More rapid improvement occurring within the first week . . .