Plasma Hemoglobin Binding and Clearance in the Rhesus Monkey After Hemolytic Transfusion Reactions

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Abstract
Summary Binding of hemoglobin by rhesus monkey plasma was studied in vitro and after hemolytic transfusion reactions in vivo. Monkey haptoglobin was found to bind the same amount of monkey or human hemoglobin and was very similar to human haptoglobin in its electrophoretic characteristics. The mean plasma haptoglobin level in 10 monkeys was 69 mg/100 ml. Following hemolytic transfusion reactions, free hemoglobin, haptoglobin-bound hemoglobin, and methemalbumin were identified in the plasma, and their disappearance was traced. The value of the rhesus monkey as an experimental animal for the study of intravascular hemolysis and plasma hemoglobin binding and metabolism is stressed.