Synthesis of 2',3'-Dideoxy-3'-methylidenethymidine and 2',3'-Didehydro-2',3'-dideoxy-3'-methylthymidine: Deoxygenation of the Allylic Alchol System in 3'-Deoxy-3'-methyodene-5-methyluridine
- 1 January 1989
- journal article
- research article
- Published by CLOCKSS Archive in HETEROCYCLES
- Vol. 29 (1) , 25-28
- https://doi.org/10.3987/com-88-4770
Abstract
Synthesis of 2'',3''-dideoxy-3''-methylidenethymidine (10) was accomplished by palladium catalyzed deoxygenation of 3''-deoxy-3''-methylidene-5-methyluridine derivative (7). 2'',3''-Didehydro-2'',3''-dideoxy-3''-methylthymidine (11) was synthesized by radical deoxygenation of 3''-deoxy-3''-methylidene-5-methyluridine derivatives.Keywords
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