Iodine-125-Labeled Triiodothyronine in Rat Brain: Evidence for Localization in Discrete Neural Systems
- 15 January 1982
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 215 (4530) , 309-312
- https://doi.org/10.1126/science.7053582
Abstract
Autoradiograms prepared from adult rat brains demonstrate that nerve cells and neuropil in different brain regions selectively concentrate and retain intravenously administered triiodothyronine, by mechanisms susceptible to saturation with excess triiodothyronine. A neuroregulatory role for thyroid hormones, strongly supported by the observations, may account for their marked effects on behavior and the activity of the autonomic nervous system.Keywords
This publication has 15 references indexed in Scilit:
- Target Cells for 1,25-Dihydroxyvitamin D 3 in Intestinal Tract, Stomach, Kidney, Skin, Pituitary, and ParathyroidScience, 1979
- Radioautographic characterization of a serotonin-accumulating nerve cell group in adult rat hypothalamusBrain Research, 1979
- Nuclear Triiodothyronine Receptor Sites in Brain: Probable Identity with Hepatic Receptors and Regional Distribution*Endocrinology, 1978
- Behavioral Neurochemistry: Neuroregulators and Behavioral StatesScience, 1978
- Hypothyroidism-Induced Changes in Triiodothyronine Binding to Nuclei and Cytosol-Binding Proteins in Rat Liver*Endocrinology, 1978
- Triiodothyronine in Rat Submaxillary Salivary Gland: Effects of Altered Adrenergic FunctionPharmacology, 1977
- Mapping of Functional Neural Pathways by Autoradiographic Survey of Local Metabolic Rate with [ 14 C]DeoxyglucoseScience, 1975
- [13] Autoradiographic techniques for localizing steroid hormonesPublished by Elsevier ,1975
- On the mechanism of action of thyroxin, an amino acid analog of tyrosineJournal of Theoretical Biology, 1974
- Fate of Thyroxin Iodine in the Neuraxis of Rana pipiens During Metamorphosis: Radioautographic StudiesStereotactic and Functional Neurosurgery, 1969