Interleukin 2 induces rapid phosphorylation of cellular proteins in murine T-lymphocytes
- 17 March 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 198 (1) , 33-37
- https://doi.org/10.1016/0014-5793(86)81179-6
Abstract
When quiescent murine T-lymphocyte cells were stimulated by the addition of interleukin 2 (IL-2), they reinitiated DNA synthesis after a lag period of 5 h. Under these conditions, rapid but transient phosphorylation of two cellular proteins with M r, values of 27000 and 26000 was detected; maximal phosphorylation occurred within 10–15 min after the addition of IL-2. The protein of M r, 27 000 contained phosphoserine, while the protein of M r 26000 contained phosphothreonine.Keywords
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