SELECTION FOR LOCAL (INTRAVAGINAL) ACTION OF OESTROGENS

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Abstract
SUMMARY: A randomly bred line of albino mice has been selected into lines of increased and decreased sensitivity to oestrogen as determined by the intravaginal action of oestrone. Ovariectomized mice were used in the tests, successive generations being bred from the sibs of test animals. The two lines showed different sensitivities when tested with oestradiol-3:17β given by the intravaginal route. When tested by the subcutaneous injection of oestrone, the two lines were of equal sensitivity. The significance of these results in relation to the mode of action of oestrogens is discussed.