Studies on the Enzymatic Systems of Rat Adrenal in Early Postnatal Period : II. The Effect of Nadph on Progesteron-4-C14Hydroxylation and Pentose Cycle Activity

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Abstract
The effect of NADPH producing sys em (G6P and NADP) on the hydroxylating capacity of rat adrenals was investigated during the early postnatal period. It was observed that the addition of the NADPH producing system to the adrenals of 16 days old rats increases the conversion of progesterone-4-14C to corticosterone twofold, and to 18-OH DOC as much as threefold. Such an effect was not observed either in the G6P itself nor in the NADP. The presence of active HMC was found in the adrenals of young rats : its activity around the 16th day became moderately increased.