Suppressor-Inducer T Cells in Multiple Sclerosis
- 9 July 1987
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 317 (2) , 118-119
- https://doi.org/10.1056/nejm198707093170216
Abstract
To the Editor: Morimoto et al. (Jan. 8 issue)1 report the loss of suppressor-inducer T cells in patients with progressive multiple sclerosis. The authors allude to our earlier study,2 noting that "a subset of T helper cells was found to be decreased in active multiple sclerosis when a different set of monoclonal antibodies was used." In fact, the monoclonal antibodies used in both studies define the same subsets of CD4+ (T4+) cells: the anti-CD4 monoclonal antibodies used by Morimoto et al. (T4) and by us (G17–2) react with the same epitope on the CD4 molecule, as evidenced by cross-blocking studies . . .Keywords
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