Effects of Exemestane and Tamoxifen in a Postmenopausal Breast Cancer Model
- 1 November 2004
- journal article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 10 (21) , 7375-7381
- https://doi.org/10.1158/1078-0432.ccr-04-0565
Abstract
Purpose: To optimize treatment strategies for postmenopausal breast cancer patients, we investigated the efficacy of the steroidal aromatase inhibitor exemestane alone or in combination with the antiestrogen tamoxifen in a xenograft model of postmenopausal breast cancer. We also determined the effects of these agents in sequential second-line therapy and the effect of the nonsteroidal aromatase inhibitor letrozole on tumors that progressed on the above treatments.Keywords
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