The One‐Point Method in Predicting Dosage Regimen in Case of Hepatic and/or Renal Failure in Presence or Absence of Change in Volume of Distribution

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Abstract
In some clinical situations, e.g., as acute myocardial or coronary infarction, liver disease, renal failure, hypoalbuminemia, displacement from protein binding, etc., both the volume of distribution and the elimination rate may change. The determination of the creatinine clearance may be too time consuming, and the serum creatinine concentration may be an unreliable indicator in some cases (acute renal failure, uremia, muscular diseases, old age, etc.). Neither indicates change in elimination by extrarenal routes (metabolism in liver disease). The repeated 1 point method is presented as clinical tool to calculate the dosage regimen for patients where differences in Vd [volume of distribution] and kel [elimination rate constant] can be expected. The method is based on the evaluation of 1 blood sample each in the first 2 dosing intervals after administration of a test dose. The repeated 1 point method is compared with the previously published 1 point method.

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