Serum biochemical changes in calves with Johne's disease

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Abstract
Calves clinically affected with experimentally induced Johne''s disease [Mycobacterium paratuberculosis] exhibited elevation of ceruloplasmin oxidase activity, and marked depression of .alpha.-mannosidase activity during the period when clinical signs of the disease were most prominent. Changes in serum Cu levels and alkaline phosphatase activity were closely correlated with the elevation of ceruloplasmin oxidase activity and depression of .alpha.-mannosidase activity. The pattern of these changes was similar to nutritional and metabolic changes described previously in acute infectious conditions in man and animals.