Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products
- 1 July 1982
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 298 (5871) , 240-244
- https://doi.org/10.1038/298240a0
Abstract
Alternative processing of RNA transcripts from the calcitonin gene results in the production of distinct mRNA encoding the hormone calcitonon or a predicted product referred to as calcitonin gene-related peptide (CGRP). The calcitonin mRNA predominates in the thyroid while the CGRP-specific mRNA appears to predominate in the hypothalamus. A model is proposed in which developmental regulation of RNA processing is used to increase the diversity of neuroendocrine gene expession.This publication has 34 references indexed in Scilit:
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