Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries.

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Abstract
Selected regions of cloned EcoRI fragments of the chicken ovalbumin gene were sequenced. The positions where the sequences coding for ovalbumin mRNA (ov-mRNA) are interrupted in the genome were determined, and a previously unreported interruption in the DNA sequences coding for the 5'' nontranslated region of the messenger was discovered. Because directly repeated sequences are found at exon-intron boundaries, the nucleotide sequence alone cannot define unique excision-ligation points for the processing of a possible ov-mRNA precursor. The sequences in these boundary regions share common features; this leads to the proposal that there are unique excision-ligation points common to all boundaries.