Urinary excretion of LATS in a patient with graves'disease complicated by nephrotic syndrome.
- 1 January 1980
- journal article
- research article
- Published by Japan Endocrine Society in Endocrinologia Japonica
- Vol. 27 (6) , 727-732
- https://doi.org/10.1507/endocrj1954.27.727
Abstract
A case report of a female patient with Graves'' disease complicated by nephrotic syndrome with high LATS [long-acting thyroid stimulator] activity in urinary .gamma.-globulin is presented. When in the hyperthyroid state with high LATS activity in the serum, she was treated with antithyroid drugs, excess I, and finally radioisotopes. Mild hypothyroidism occurred transiently without any significant change in serum LATS activity. Nephrotic syndrome suddenly appeared. Urinary IgG was purified by salting out with ammonium sulfate, DEAE and protein A-Sepharose, and LATS activity in the purified urinary IgG fraction was demonstrated. The specific activity of LATS activity in urinary IgG protein was slightly lower than that of the serum. This is the 1st demonstration of LATS activity in urine from a patient with hyperthyroidism and nephrotic syndrome.This publication has 6 references indexed in Scilit:
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