Neonatal lupus erythematosus. Report of four cases with review of the literature

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Abstract
Four newborn infants with a distinctive evanescent cutaneous eruption that clinically and histologically resembled lupud erythematosus were reported; 2 of the mothers had undifferentiated connective tissue disease. The tendency for lesions to occur in a periobital location and the association of prominent telanglectasias were characteristic clinical signs in the patients. Immunoglobulin deposition at the basement membrane was demonstrated in 1 patient. Cytogenetic studies, done to exclude Bloom syndrome, revealed only nonspecific chromosomal abnormalities. A brief review of the literature, with speculations on the possible relationship of these changes to the occurrence of connective tissue disease in the mothers, is included in the discussion.