GLOMERULAR DEPOSITION OF RENAL TUBULAR EPITHELIAL ANTIGEN IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS - ITS POSSIBLE ROLE IN LUPUS NEPHRITIS

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 4  (4) , 358-368
Abstract
Fifty-three renal specimens from 48 patients with SLE [systemic lupus erythematosis] were examined for the presence of RTE [renal tubular epithelial antigen] in the glomeruli. Glomerular RTE, presumably in immune complex form, was detected in 60% of the tissues. The deposition of these complexes was related to the severity of histologic changes and activity of SLE. Glomerular localization of RTE was associated with decreased renal function and increased proteinuria. The association between the presence of glomerular RTE antigen, the severity of renal histologic changes and the decreased renal function suggested a possible role for this antigen in the pathogenesis of lupus nephritis.

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