Relationship between Plasma, Dentin and Bone Fluoride Concentrations in Rats following Long‐term Fluoride Administration

Publisher Website
Google Scholar
Abstract
A detailed knowledge of fluoride (F) pharmacokinetics is necessary if its pharmacologic and toxicologic effects are to be adequately understood. In the present study plasma F concentrations were analyzed using repeated blood samples taken from the ethmoidal sinus of rats given 25, 50, 100 and 150 ppm F in drinking water ad lib for 79 days. A close relationship between the F-concentration in the drinking water and plasma F concentrations was found. When the administration of F was stopped, a rapid decline in plasma F concentration was noted during 48 h in all groups. The plasma F concentrations in the 25 ppm group returned to preexperimental levels but remained elevated in the other groups. The F concentrations of dentin and bone are determined and calculated on a dry fat free basis. There was a close relationship between plasma, bone and dentin concentrations.