Flow-Pressure Relationships in Newborn and Infant Spontaneously Hypertensive Rats

Publisher Website
Google Scholar
Abstract
In flow-pressure studies of the perfused forebody, newborn (3-12 h old) SHR [spontaneously hypertensive rats] demonstrated significantly lower pressures than newborn WKY [normotensive Wistar-Kyoto rats] at high flow rates. Newborns from dams fed high salt during pregnancy showed no significant differences in flow-pressure relationships from newborns of the corresponding strain whose dams received standard salt. At 2 wk, SHR continued on standard salt had pressures not significantly different from those of WKY at intermediate and high flow rates. However, 2-wk standard salt SHR demonstrated significantly lower pressures at low perfusion rates than 2-wk WKY. Two-week SHR on high salt showed strikingly lower pressures at high flows than 2-wk standard salt SHR.