A Long-Time Study of the Blood Lipids of Two Students of Atherosclerosis

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Abstract
A study of serum cholesterol and lipoproteins covering periods of 28 years in a male physician and 17 years in a female research worker showed relative constancy for the cholesterol levels and greater variability for the lipoproteins. Cholesterol was reduced sharply and temporarily just after each influenzal infection. In the male, the level of cholesterol was slightly above 300 mg/100 ml for more than 13 years. An extremely low cholesterol and high carbohydrate diet proved unacceptable. A more liberal, relatively low-saturated fat, low-cholesterol, and high polyunsaturated fatty acid diet with about 30% of the calories from fat, maintained the cholesterol level between 230 and 270 mg and has been followed with relish for a number of years. A myocardial infarction occurred 27 years after the study began. Clofibrate since then has reduced the cholesterol level further. The female subject is in good health and maintains cholesterol levels slightly below 300 mg on a usual American diet. She is 10 years younger than the male. Her —S 40-70 lipoproteins have usually been well below the male subject's. Weight gain and lack of exercise seemed regularly to increase both levels. The data are presented because we believe them to be accurate; their interpretation is for the reader. We hope he must wait for some time for the outcome of the study.

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