Evidence that mAMSA induces topoisomerase action
- 5 September 1983
- journal article
- Published by Wiley in FEBS Letters
- Vol. 161 (1) , 75-78
- https://doi.org/10.1016/0014-5793(83)80733-9
Abstract
Evidence is presented that the topoisomerase inhibitors novobiocin and coumermycin inhibit the production of double-strand breaks in mouse mastocytoma cell nuclear DNA by the anticancer drug 4′[(9-acridinyl)amino]-methanesulphon-m-anisidide (mAMSA). Novobiocin did not inhibit resealing of DNA breaks induced by mAMSA. It is suggested that mAMSA intercalation into DNA induces the action of a type II topoisomerase. mAMSA and oAMSA were equally effective in breaking the DNA in isolated nuclei.Keywords
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