RESTRICTION ENDONUCLEASE MAPPING OF GAMMA-DELTA-BETA-GLOBIN REGION IN G-GAMMA(BETA)+ HPFH AND A CHINESE A-GAMMA-HPFH VARIANT
- 1 January 1983
- journal article
- research article
- Vol. 35 (4) , 611-620
Abstract
Restriction endonuclease mapping of the .beta.-globin genomic region was used for studying the molecular basis of 2 variants of hereditary persistence of fetal Hb (HPFH): an African G.gamma.(.beta.)+ HPFH and a Chinese HPFH variant with predominant synthesis of A.gamma. chains. HPFH and control DNA samples were digested with a battery of restriction enzymes, and the fragments were identified by hybridization to a family of discrete probes. DNA fragments from the A.gamma. HPFH (Chinese) and the G.gamma.(.beta.)+ HPFH individuals were identical with those of the normal controls. The 2 mutants may be the result of small structural anomalies of DNA sequences that play a role in the regulation of the expression of .gamma.-globulin genes.This publication has 44 references indexed in Scilit:
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