MECHANISM OF INSULIN-SECRETION AFTER ORAL GLUCOSE ADMINISTRATION .8. PANCREATIC-JUICE INSULIN EXCRETION AFTER GLUCOSE LOADING AND MEAL INGESTION IN NORMAL AND VAGOTOMIZED DOGS
- 1 January 1976
- journal article
- research article
- Vol. 68 (3) , 327-337
Abstract
On pancreatic fistula dogs, immunoreactive insulin [IRI] was identified in pancreatic juice. Insulin excretion is inhibited by an i.v. glucose load and stimulated in a biphasic manner by an oral glucose load or by ingestion of mashed meat. Insulin excretion is reduced 2 mo. after bilateral truncular vagotomy, and the reaction to both oral stimuli is abolished. There is no statistical correlation between pancreatic juice insulin and blood glucose, plasma IRI or plasma amino N concentrations. Single extrainsular .beta.-cells shown by histologic examination are probably the source of pancreatic juice insulin. Compared to insulin secreted into the portal blood flow, insulin in the pancreatic juice amounts to only 0.1-0.2% of the daily secretory rate of the islets of Langerhans.This publication has 3 references indexed in Scilit:
- MECHANISM OF INSULIN-SECRETION AFTER ORAL GLUCOSE ADMINISTRATION .7. EXOCRINE PANCREATIC FUNCTION AND PLASMA-IRI IN DOGS WITH CHRONIC PANCREATIC FISTULAS1976
- INFLUENCE OF VAGOTOMY UPON GLUCOSE-TOLERANCE AND RESPONSES OF PLASMA-INSULIN AND EXOCRINE PANCREATIC FUNCTION FOLLOWING GLUCOSE-LOAD OR FOOD INGESTION OF DOGS1976
- Liver and insulin: Presence of insulin in bileMetabolism, 1967