Differential expression of H-2Dd and H-2Ld histocompatibility antigens.
Open Access
- 1 February 1985
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 161 (2) , 356-365
- https://doi.org/10.1084/jem.161.2.356
Abstract
To determine why the H-2Dd antigen is expressed on the surface of transfected [mouse] cells at a rate several-fold higher than an analogously transfected H-2Ld molecule, both previously described and new H-2 hybrid genes were analyzed. These genes were constructed by exchanging domains between H-2 genes. Quantitative radioimmunoassay indicates that the region of the H-2Dd molecule responsible for its enhanced expression resides in the polymorphic N domain, the first domain of the mature class I molecule.This publication has 30 references indexed in Scilit:
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