Lessons Learned From Recent Cardiovascular Clinical Trials: Part I
Open Access
- 6 August 2002
- journal article
- review article
- Published by Wolters Kluwer Health in Circulation
- Vol. 106 (6) , 746-751
- https://doi.org/10.1161/01.cir.0000023219.51483.66
Abstract
Background— Leaflet curvature is known to reduce mechanical stress. There are 2 major components that contribute to this curvature. Leaflet billowing introduces the most obvious form of leaflet curvature. The saddle shape of the mitral annulus imparts a more subtle form of leaflet curvature. This study explores the relative contributions of leaflet billowing and annular shape on leaflet curvature and stress distribution.Keywords
This publication has 46 references indexed in Scilit:
- Reperfusion therapy for acute myocardial infarction with fibrinolytic therapy or combination reduced fibrinolytic therapy and platelet glycoprotein IIb/IIIa inhibition: the GUSTO V randomised trialThe Lancet, 2001
- Neurohormonal activation in severe heart failure: Relations to patient death and the effect of treatment with flosequinanAmerican Heart Journal, 2000
- Surrogate end points in cardiovascular disease trialsAmerican Heart Journal, 2000
- The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trialThe Lancet, 1999
- Rationale, Design, and Organization of the Metoprolol CR/XL Randomized Intervention Trial in Heart Failure (MERIT-HF)The American Journal of Cardiology, 1997
- Experimental Approaches to Determining the Choice of First-Step Therapy for Patients with HypertensionClinical and Experimental Hypertension, 1996
- Family spacing, breastfeeding, and contraceptionThe Lancet, 1994
- An International Randomized Trial Comparing Four Thrombolytic Strategies for Acute Myocardial InfarctionNew England Journal of Medicine, 1993
- Preliminary Report: Effect of Encainide and Flecainide on Mortality in a Randomized Trial of Arrhythmia Suppression after Myocardial InfarctionNew England Journal of Medicine, 1989
- Final Report on the Aspirin Component of the Ongoing Physicians' Health StudyNew England Journal of Medicine, 1989