Sensitivity of Male dba Mice to the Toxicity of Chloroform as a Laboratory Hazard
- 13 March 1953
- journal article
- letter
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 117 (3037) , 285
- https://doi.org/10.1126/science.117.3037.285
Abstract
The male dba mouse is sensitive to the toxic effects of chloroform to such a degree as to constitute an unusual laboratory hazard, dying within 6-8 days after being in a room with, or near a beaker of, exposed chloroform. At autopsy the kidneys were large, pale, and swollen, and microscopically had gross tubular necrosis. Under similar conditions, female dba mice show a slight fatty degeneration of the liver, but are not otherwise affected.Keywords
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