Evolution of cadmium-induced renal dysfunction in workers removed from exposure.

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Abstract
A retrospective examination of the medical records gathered during several surveys carried out among Cd workers permitted the identification of a group of 19 workers who had been examined before and after removal from Cd exposure. All the workers had been exposed for > 15 yr (range 15.6-41.7 yr). Their last examination took place 0.3-7.9 yr after the date of removal from Cd exposure. At that time, all the workers exhibited sign(s) of Cd-induced renal dysfunction. Comparison of the renal function parameters (serum creatinine, total proteinuria, aminoaciduria, albuminuria, .beta.2-microglobulinuria and the urinary excretion of retinol-binding protein) before and after the cessation of exposure indicated that Cd-induced renal lesions, albeit of slow progression, were not reversible when exposure ceased.