Urinary Excretion of Adenosine 3'5‘ Monophosphate in Vitamin D Deficiency

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Abstract
Urinary c(cyclic)AMP excretion was determined by radioimmunoassay in children with rickets and in control children. cAMP was greatly increased in children with rickets. The excretion of cAMP correlated significantly with parathyroid hormone levels (PTH) and alkaline phosphatase, but not with age, calcemia and serum inorganic phosphate. Ca infusion led to a decrease in the excretion of cAMP. The data are consistent with following hypothesis. During vitamin D deficiency, high PTH levels can increase the renal excretion of cAMP. The effects of PTH on bone resorption fail to maintain the levels of serum Ca due to the lack of vitamin D. The mechanism by which the secondary hyperparathyroidism develops during vitamin D deficiency remains to be investigated.

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