Parental origin of chromosome abnormalities in spontaneous abortions
- 1 December 1982
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 62 (2) , 129-133
- https://doi.org/10.1007/bf00282300
Abstract
Tissue cultures were initiated from 130 spontaneous abortion specimens and 81 were successfully karyotyped. Chromosome abnormalities were found in 50 cases: 12 with XO, 27 with trisomy, 6 with triploidy, 1 with tetraploidy and 4 others. The parental origin was determined in 11 cases of trisomy for an acrocentric chromosome. Two cases were uninformative while 9 non-disjunctions were determined and occurred during meiosis I: 7 were maternal and 2 paternal (both with trisomy 21). Three out of 7 cases with trisomy 16 were informative and resulted from a divisional error during the first meiotic division in the mother. All cases of triploidy were informative. They resulted from non-reduction during meiosis I in the mother (2) or dispermy (4).This publication has 18 references indexed in Scilit:
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