Reaction of human UMP‐CMP kinase with natural and analog substrates
Open Access
- 25 March 2003
- journal article
- research article
- Published by Wiley in European Journal of Biochemistry
- Vol. 270 (8) , 1784-1790
- https://doi.org/10.1046/j.1432-1033.2003.03537.x
Abstract
UMP‐CMP kinase catalyses an important step in the phosphorylation of UTP, CTP and dCTP. It is also involved in the necessary phosphorylation by cellular kinases of nucleoside analogs used in antivira...Keywords
This publication has 32 references indexed in Scilit:
- Antiviral l -Nucleosides Specific for Hepatitis B Virus InfectionAntimicrobial Agents and Chemotherapy, 2001
- Stereoisomeric Selectivity of Human Deoxyribonucleoside KinasesBiochemistry, 1999
- L-ATP is recognized by some cellular and viral enzymes: does chance drive enzymic enantioselectivity?Biochemical Journal, 1999
- CMP Kinase from Escherichia coli Is Structurally Related to Other Nucleoside Monophosphate KinasesJournal of Biological Chemistry, 1996
- Structural Properties of UMP-Kinase from Escherichia coli: Modulation of Protein Solubility by pH and UTPBiochemistry, 1996
- Crystal Structure of the Complex of UMP/CMP Kinase from Dictyostelium discoideum and the Bisubstrate Inhibitor P1-(5‘-Adenosyl) P5-(5‘-Uridyl) Pentaphosphate (UP5A) and Mg2+ at 2.2 Å: Implications for Water-Mediated SpecificityBiochemistry, 1996
- Lack of stereospecificity of some cellular and viral enzymes involved in the synthesis of deoxyribonucleotides and DNA: Molecular basis for the antiviral activity of unnatural l-β-nucleosidesBiochimie, 1995
- Substrate Specificity and Assembly of the Catalytic Center Derived from two Structures of Ligated Uridylate KinaseJournal of Molecular Biology, 1995
- The Structure of Uridylate Kinase with Its Substrates, Showing the Transition State GeometryJournal of Molecular Biology, 1994
- Isolation and characterization of catalytic and calmodulin‐binding domains of Bordetella pertussis adenylate cyclaseEuropean Journal of Biochemistry, 1991