Lack of stereospecificity of some cellular and viral enzymes involved in the synthesis of deoxyribonucleotides and DNA: Molecular basis for the antiviral activity of unnatural l-β-nucleosides

This publication has 12 references indexed in Scilit:

• Stereospecificity of human DNA polymerases α,β,γ,§ and ɛ, HIV-reverse transcriptase, HSV- DNA polymerase, calf thymus terminal transferase andEscherichia coliDNA polymerase I in recognizing D- and L-thymidine 5′-triphosphate as substrate
  Nucleic Acids Research, 1995
• Selectivity of DNA polymerases toward α and β nucleotide substrates ofdandlseries
  FEBS Letters, 1994
• Anti-human immunodeficiency virus activities of the beta-L enantiomer of 2',3'-dideoxycytidine and its 5-fluoro derivative in vitro
  Antimicrobial Agents and Chemotherapy, 1994
• Chiral Discrimination of Enantiomeric 2′-Deoxythymidine 5′-Triphosphate by HIV-1 Reverse Transcriptase and Eukaryotic DNA Polymerases
  Biochemical and Biophysical Research Communications, 1994
• Lack of stereospecificity of suid pseudorabies virus thymidine kinase
  Biochemical Journal, 1993
• Affinity of the antiviral enantiomers of oxathiolane cytosine nucleosides for human 2′-deoxycytidine kinase
  Biochemical Pharmacology, 1993
• L-Thymidine is phosphorylated by herpes simplex virus type 1 thymidine kinase and inhibits viral growth
  Journal of Medicinal Chemistry, 1992
• Total Chemical Synthesis of a D-Enzyme: The Enantiomers of HIV-1 Protease Show Reciprocal Chiral Substrate Specificity
  Science, 1992
• Comparison of the substrate specificities of human thymidine kinase 1 and 2 and deoxycytidine kinase toward antiviral and cytostatic nucleoside analogs
  Biochemical and Biophysical Research Communications, 1991
• Phosphorolysis of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and other 5-substituted-2'-deoxyuridines by purified human thymidine phosphorylase and intact blood platelets
  Biochemical Pharmacology, 1983