Effect of Dipyridamole on the Survival of Experimental Critical Skin Flaps
- 1 January 1979
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Plastic and Reconstructive Surgery
- Vol. 13 (2) , 261-262
- https://doi.org/10.3109/02844317909013067
Abstract
The effect of dipyridamole (Persantin) on the survival of experimental skin flaps was studied [in rats]. In controls 39% of the skin flap area survived. I.p. injection of dipyridamole 4 mg/kg twice daily starting 4 h preoperatively increased the surviving area by 18%. This increase is statistically significant (P < 0.05). The improved survival could be due to the vasodilatory action of the drug and/or proliferation of small blood vessels induced by the drug.This publication has 4 references indexed in Scilit:
- Antilipolytic Effect of Adenosine in Dog Adipose Tissue in SituActa Physiologica Scandinavica, 1977
- Increased Survival of Experimental Skin Flaps in Rats Following Treatment with Antiadrenergic DrugsScandinavian Journal of Plastic and Reconstructive Surgery, 1976
- Uptake and metabolism of adenosine by human erythrocyte ghostsAmerican Journal of Physiology-Legacy Content, 1972
- Improvement of blood circulation in experimental skin flaps by phentolamineEuropean Journal of Pharmacology, 1969