A new method to test genetic models in HLA associated diseases: the MASC method

1 July 1988

journal article
Published by Wiley in Annals of Human Genetics

Vol. 52 (3) , 247-258
https://doi.org/10.1111/j.1469-1809.1988.tb01102.x

Abstract

We propose a new method to analyse data on HLA associated diseases. The method uses the simultaneous information on the marker associations and segregation with the disease. It may also take into account the differential risk of being affected for specific relatives of a patient as well as the differential HLA haplotype sharing according to the marker genotype of the patient. It is based on the principle of minimization of a sum of independent chi‐squares. It allows us to test the goodness‐of‐fit of various models in an easy and economical way. The method is applied to a sample of 269 French IDDM patients and their relatives leading to the rejection of models with one locus closely linked to HLA with two and three alleles.

Keywords

This publication has 10 references indexed in Scilit:

Chi-squared tests with small numbers
Annals of Human Genetics, 1986
Discrimination between genetic models for insulin dependent diabetes mellitus
Genetic Epidemiology, 1986
Combined analysis of genetic segregation and linkage under an oligogenic model
Computers and Biomedical Research, 1984
HLA and susceptibility to multiple sclerosis
Tissue Antigens, 1984
A general model for disease‐marker association
Annals of Human Genetics, 1983
Investigation of the mode of inheritance of the HLA associated diseases by the method of antigen genotype frequencies among diseased individuals
Tissue Antigens, 1983
The Affected Sib Pair IBD Distribution for HLA‐Linked Disease Susceptibility Genes
Tissue Antigens, 1978
The Genetics of HLA and Disease Associations
Published by Springer Nature ,1977
Disease Susceptibility Genes ‐ their Identification by Multiple Case Family Studies
Tissue Antigens, 1976
Disease Susceptibility Genes ‐ their Identification by Multiple Case Family Studies
Tissue Antigens, 1976