Measurements of Blood Flow Velocity in the Microcirculation

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Abstract
A method for the measurement of red blood cell velocity in the microcirculation is described. The technique is based on the on-line cross-correlation measurement of the delay between optical signatures derived from photodetectors aligned in direction of flow. A specialised photodiode holder which can be inserted directly in place of an ocular is described. The interdetector delay data is computed automatically from the cross-correlation function by a peak detector designed to provide a voltage proportional to the delay to maximum cross-correlation, regardless of intermediate lower peaks. Application of this system to measurements in the rabbit ear chamber, mesentery and skeletal muscle is described.