Studies with Clearing Factor V. State of Tissue Lipases After Injection of Heparin.

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Abstract
Injection of heparin into rats induced an increase in lipase activity of the plasma and a decrease in lipase activity of the tissues. The recovery of lipase levels in the tissues was observed after 2 to 3 hr. Before and after heparin injection the ratio of lipase activity inhibited by protamine sulfate and NaCl to lipase activity resistant to these inhibitors was not constant. After heparin injection increased activity of [beta]-monoglyceridase in the tissues was observed. The tissues (of the nonheparin-injected rats) treated with epinephrine exhibited significant increases in lipase activity. No marked increase in lipase activity was observed in the tissues (of heparin-injected rats) treated with epinephrine.