CELL ADHESION MOLECULES AND COLON CANCER
- 1 December 1996
- journal article
- Published by Wiley in Anz Journal of Surgery
- Vol. 66 (12) , 791-798
- https://doi.org/10.1111/j.1445-2197.1996.tb00752.x
Abstract
There is a general consensus that cell-cell and cell-matrix interactions determine, at least in part, the behaviour of colon cancer. The biological mediators responsible for these interactions are cell adhesion molecules belonging to several major receptor families called integrins, cadherins, the immunoglobulin superfamily, hyaluronate receptors and mucins. Emerging data indicate that certain patterns of adhesion receptor expression are associated with more aggressive disease. The present review examines the role of each of the receptor families in the development and progression of large bowel cancer.Keywords
This publication has 71 references indexed in Scilit:
- Metastatic potential of human colorectal carcinoma SW1222 cells transfected with cDNA encoding carcinoembryonic antigenClinical & Experimental Metastasis, 1994
- Integrins: Versatility, modulation, and signaling in cell adhesionCell, 1992
- Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): cytolytic activity and proliferation of NK cells are differentially regulated by NKSF.The Journal of Experimental Medicine, 1992
- Diminished expression of integrin adhesion molecules on human colonic epithelial cells during the benign to malign tumour transformation.Gut, 1992
- Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor roleCell, 1991
- CD44 is the principal cell surface receptor for hyaluronateCell, 1990
- Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion moleculePublished by Elsevier ,1989
- The function of multiple extracellular matrix receptors in mediating cell adhesion to extracellular matrix: preparation of monoclonal antibodies to the fibronectin receptor that specifically inhibit cell adhesion to fibronectin and react with platelet glycoproteins Ic-IIa.The Journal of cell biology, 1988
- Genetic Alterations during Colorectal-Tumor DevelopmentNew England Journal of Medicine, 1988
- The Lymphocyte Function Associated LFA-1, CD2, and LFA-3 Molecules: Cell Adhesion Receptors of the Immune SystemAnnual Review of Immunology, 1987