SERUM PROTEIN-BOUND IODINE AND SERUM THYROXINE DURING PERPHENAZINE THERAPY
- 1 May 1967
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 55 (1) , 136-145
- https://doi.org/10.1530/acta.0.0550136
Abstract
Four out of 19 patients treated with perphenazine who were investigated in 1962, and 5 out of 31 patients who were investigated in 1966 had a raised PBI. The increase was most marked in the patients investigated in 1962. Measurements of dialysable thyroxine revealed that the increase was not due to an increase in thyroxine-binding globulin. All 50 patients had normal serum thyroxine as estimated by Murphy''s method. Most probably the increase in PBI was due to the fact that the perphenazine tablets contain an iodine compound, which in some subjects may become bound to the serum proteins.This publication has 4 references indexed in Scilit:
- PROLONGED PERPHENAZINE THERAPY AND THYROID FUNCTIONAmerican Journal of Psychiatry, 1963
- The distribution and excretion of radioactivity after administration of 35S-labeled perphenazine (Trilafon)Biochemical Pharmacology, 1962
- Separation of Iodine Compounds is Serum by Gel FiltrationScandinavian Journal of Clinical and Laboratory Investigation, 1962
- THE CLINICAL DETERMINATION OF PROTEIN-BOUND IODINE 1Journal of Clinical Investigation, 1951