Sclerotigenin: A New Antiinsectan Benzodiazepine from the Sclerotia of Penicillium sclerotigenum
- 25 March 1999
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 62 (4) , 650-652
- https://doi.org/10.1021/np980511n
Abstract
A new benzodiazepine, sclerotigenin (1), was isolated from organic extracts of the sclerotia of Penicillium sclerotigenum (NRRL 3461) along with two known griseofulvin analogues. The structure of 1 was determined primarily by analysis of 1H NMR, 13C NMR, HMQC, and HMBC data. Compound 1 was the major component of the CH2Cl2 extract of P. sclerotigenum sclerotia and is responsible for most of the antiinsectan activity of the extract against the crop pest Helicoverpa zea.Keywords
This publication has 10 references indexed in Scilit:
- New p-Terphenyl and Polyketide Metabolites from the Sclerotia of Penicillium raistrickiiJournal of Natural Products, 1998
- Antiinsectan natural products from fungal sclerotiaAccounts of Chemical Research, 1995
- Atropisomers of 1,4-benzodiazepines. Synthesis and resolution of a diazepam-related 1,4-benzodiazepineJournal of the American Chemical Society, 1990
- The Systematics of the Terverticillate PenicilliaPublished by Springer Nature ,1990
- Sclerotial metabolites of Aspergillus Flavus toxic to a detritivorous maize insect (Carpophilus Hemipterus, Nitidulidae)Transactions of the British Mycological Society, 1988
- On the biosynthesis of asperlicin and the directed biosynthesis of analogs in Aspergillus alliaceus.The Journal of Antibiotics, 1988
- Novel cholecystokinin antagonists from Aspergillus alliaceus. II. Structure determination of asperlicins B, C, D, and E.The Journal of Antibiotics, 1988
- Cloning of Shiga-like toxin structural genes from a toxin converting phage of Escherichia coliScience, 1985
- Asperlicin, a novel non-peptidal cholecystokinin antagonist from Aspergillus alliaceus. Structure elucidation.The Journal of Antibiotics, 1985
- Benzonorbornene and derivatives. VII. Benzonorbornene-endo-2-carboxylic acid and its methyl esterThe Journal of Organic Chemistry, 1975